HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels

A fundamental question is how autophagosome formation is regulated. Here we show that the PX domain protein HS1BP3 is a negative regulator of autophagosome formation. HS1BP3 depletion increased the formation of LC3-positive autophagosomes and degradation of cargo both in human cell culture and in ze...

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Detalles Bibliográficos
Autores principales: Holland, Petter, Knævelsrud, Helene, Søreng, Kristiane, Mathai, Benan J., Lystad, Alf Håkon, Pankiv, Serhiy, Bjørndal, Gunnveig T., Schultz, Sebastian W., Lobert, Viola H., Chan, Robin B., Zhou, Bowen, Liestøl, Knut, Carlsson, Sven R., Melia, Thomas J., Di Paolo, Gilbert, Simonsen, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412012/
https://www.ncbi.nlm.nih.gov/pubmed/28004827
http://dx.doi.org/10.1038/ncomms13889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412012/
https://www.ncbi.nlm.nih.gov/pubmed/28004827
http://dx.doi.org/10.1038/ncomms13889

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