SUMO-Specific Cysteine Protease 1 Promotes Epithelial Mesenchymal Transition of Prostate Cancer Cells via Regulating SMAD4 deSUMOylation

In advanced prostate cancer, small ubiquitin-like modifier (SUMO)-specific cysteine protease 1 (SENP1) is up-regulated. However, the role of SENP1 in regulating deSUMOylation of TGF-β/SMADs signaling is unknown. In this study, we developed a lentiviral vector, PLKO.1-shSENP1, to silence SENP1 in pro...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaoyan, Wang, Hao, Wang, Hua, Xiao, Fengjun, Seth, Prem, Xu, Weidong, Jia, Qinghua, Wu, Chutse, Yang, Yuefeng, Wang, Lisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412392/
https://www.ncbi.nlm.nih.gov/pubmed/28417919
http://dx.doi.org/10.3390/ijms18040808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412392/
https://www.ncbi.nlm.nih.gov/pubmed/28417919
http://dx.doi.org/10.3390/ijms18040808

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