Evaluation of the Potential Risk of Drugs to Induce Hepatotoxicity in Human—Relationships between Hepatic Steatosis Observed in Non-Clinical Toxicity Study and Hepatotoxicity in Humans-

In the development of drugs, we sometimes encounter fatty change of the hepatocytes (steatosis) which is not accompanied by degenerative change in the liver in non-clinical toxicity studies. In this study, we investigated the relationships between fatty change of the hepatocytes noted in non-clinica...

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Detalles Bibliográficos
Autores principales: Goda, Keisuke, Kobayashi, Akio, Takahashi, Akemi, Takahashi, Tadakazu, Saito, Kosuke, Maekawa, Keiko, Saito, Yoshiro, Sugai, Shoichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412394/
https://www.ncbi.nlm.nih.gov/pubmed/28417920
http://dx.doi.org/10.3390/ijms18040810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412394/
https://www.ncbi.nlm.nih.gov/pubmed/28417920
http://dx.doi.org/10.3390/ijms18040810

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