Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells

Background: Fisetin (3,7,3′,4′-tetrahydroxyflavone) is a dietary flavonol and exhibits antioxidant, anti-inflammatory, and neuroprotective activities. However, high concentration of fisetin is reported to produce reactive oxygen species (ROS), induce endoplasmic reticulum (ER) stress and cause cytot...

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Detalles Bibliográficos
Autores principales: Yen, Jui-Hung, Wu, Pei-Shan, Chen, Shu-Fen, Wu, Ming-Jiuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412436/
https://www.ncbi.nlm.nih.gov/pubmed/28420170
http://dx.doi.org/10.3390/ijms18040852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412436/
https://www.ncbi.nlm.nih.gov/pubmed/28420170
http://dx.doi.org/10.3390/ijms18040852

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