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Control of Kir channel gating by cytoplasmic domain interface interactions

Inward rectifier potassium (Kir) channels are expressed in almost all mammalian tissues and play critical roles in the control of excitability. Pancreatic ATP-sensitive K (K(ATP)) channels are key regulators of insulin secretion and comprise Kir6.2 subunits coupled to sulfonylurea receptors. Because...

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Detalles Bibliográficos
Autores principales: Borschel, William F., Wang, Shizhen, Lee, Sunjoo, Nichols, Colin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412532/
https://www.ncbi.nlm.nih.gov/pubmed/28389584
http://dx.doi.org/10.1085/jgp.201611719