Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation

Integrin activation is an indispensable step for various integrin-mediated biological functions. Kindlin-2 is known to coactivate integrins with Talin; however, molecules that restrict integrin activation are elusive. Here, we demonstrate that the E3 ubiquitin ligase Smurf1 controls the amount of Ki...

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Detalles Bibliográficos
Autores principales: Wei, Xiaofan, Wang, Xiang, Zhan, Jun, Chen, Yuhan, Fang, Weigang, Zhang, Lingqiang, Zhang, Hongquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412569/
https://www.ncbi.nlm.nih.gov/pubmed/28408404
http://dx.doi.org/10.1083/jcb.201609073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412569/
https://www.ncbi.nlm.nih.gov/pubmed/28408404
http://dx.doi.org/10.1083/jcb.201609073

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