Deletion of F4L (ribonucleotide reductase) in vaccinia virus produces a selective oncolytic virus and promotes anti‐tumor immunity with superior safety in bladder cancer models

Bladder cancer has a recurrence rate of up to 80% and many patients require multiple treatments that often fail, eventually leading to disease progression. In particular, standard of care for high‐grade disease, Bacillus Calmette–Guérin (BCG), fails in 30% of patients. We have generated a novel onco...

Descripción completa

Detalles Bibliográficos
Autores principales: Potts, Kyle G, Irwin, Chad R, Favis, Nicole A, Pink, Desmond B, Vincent, Krista M, Lewis, John D, Moore, Ronald B, Hitt, Mary M, Evans, David H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412795/
https://www.ncbi.nlm.nih.gov/pubmed/28289079
http://dx.doi.org/10.15252/emmm.201607296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412795/
https://www.ncbi.nlm.nih.gov/pubmed/28289079
http://dx.doi.org/10.15252/emmm.201607296

Ejemplares similares