An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine‐56

The stress‐inducible molecular chaperone, HSP72, is an important therapeutic target in oncology, but inhibiting this protein with small molecules has proven particularly challenging. Validating HSP72 inhibitors in cells is difficult owing to competition with the high affinity and abundance of its en...

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Detalles Bibliográficos
Autores principales: Pettinger, Jonathan, Le Bihan, Yann‐Vaï, Widya, Marcella, van Montfort, Rob L. M., Jones, Keith, Cheeseman, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412842/
https://www.ncbi.nlm.nih.gov/pubmed/28225177
http://dx.doi.org/10.1002/anie.201611907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412842/
https://www.ncbi.nlm.nih.gov/pubmed/28225177
http://dx.doi.org/10.1002/anie.201611907

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