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An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine‐56
The stress‐inducible molecular chaperone, HSP72, is an important therapeutic target in oncology, but inhibiting this protein with small molecules has proven particularly challenging. Validating HSP72 inhibitors in cells is difficult owing to competition with the high affinity and abundance of its en...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412842/ https://www.ncbi.nlm.nih.gov/pubmed/28225177 http://dx.doi.org/10.1002/anie.201611907 |