Developing a Bayesian adaptive design for a phase I clinical trial: a case study for a novel HIV treatment

The design of phase I studies is often challenging, because of limited evidence to inform study protocols. Adaptive designs are now well established in cancer but much less so in other clinical areas. A phase I study to assess the safety, pharmacokinetic profile and antiretroviral efficacy of C34‐PE...

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Detalles Bibliográficos
Autores principales: Mason, Alexina J., Gonzalez‐Maffe, Juan, Quinn, Killian, Doyle, Nicki, Legg, Ken, Norsworthy, Peter, Trevelion, Roy, Winston, Alan, Ashby, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412923/
https://www.ncbi.nlm.nih.gov/pubmed/27891651
http://dx.doi.org/10.1002/sim.7169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412923/
https://www.ncbi.nlm.nih.gov/pubmed/27891651
http://dx.doi.org/10.1002/sim.7169

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