Cargando…
Self-adjusting synthetic gene circuit for correcting insulin resistance
By using tools from synthetic biology, sophisticated genetic devices can be assembled to reprogram mammalian cell activities. Here, we demonstrate that a self-adjusting synthetic gene circuit can be designed to sense and reverse the insulin-resistance syndrome in different mouse models. By functiona...
Autores principales: | Ye, Haifeng, Xie, Mingqi, Xue, Shuai, Charpin-El Hamri, Ghislaine, Yin, Jianli, Zulewski, Henryk, Fussenegger, Martin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412959/ https://www.ncbi.nlm.nih.gov/pubmed/28480128 http://dx.doi.org/10.1038/s41551-016-0005 |
Ejemplares similares
-
A synthetic biology-based device prevents liver injury in mice
por: Bai, Peng, et al.
Publicado: (2016) -
A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice
por: Rössger, Katrin, et al.
Publicado: (2013) -
Antagonistic control of a dual-input mammalian gene switch by food additives
por: Xie, Mingqi, et al.
Publicado: (2014) -
A synthetic free fatty acid-regulated transgene switch in mammalian cells and mice
por: Liu, Ying, et al.
Publicado: (2018) -
Engineering a Rapid Insulin Release System Controlled By Oral Drug Administration
por: Mahameed, Mohamed, et al.
Publicado: (2022)