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Correction of PTEN mutations in glioblastoma cell lines via AAV-mediated gene editing
PTEN is among the most commonly mutated tumor suppressor genes in human cancer. However, studying the role of PTEN in the pathogenesis of cancer has been limited, in part, by the paucity of human cell-based isogenic systems that faithfully model PTEN loss. In an effort to remedy this problem, gene e...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413031/ https://www.ncbi.nlm.nih.gov/pubmed/28464039 http://dx.doi.org/10.1371/journal.pone.0176683 |