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Erroneous energy-generating cycles in published genome scale metabolic networks: Identification and removal

Energy metabolism is central to cellular biology. Thus, genome-scale models of heterotrophic unicellular species must account appropriately for the utilization of external nutrients to synthesize energy metabolites such as ATP. However, metabolic models designed for flux-balance analysis (FBA) may c...

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Detalles Bibliográficos
Autores principales: Fritzemeier, Claus Jonathan, Hartleb, Daniel, Szappanos, Balázs, Papp, Balázs, Lercher, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413070/
https://www.ncbi.nlm.nih.gov/pubmed/28419089
http://dx.doi.org/10.1371/journal.pcbi.1005494