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NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes
Inflammation in the brain accompanies several high-impact neurological diseases including multiple sclerosis (MS), stroke, and Alzheimer’s disease. Neuroinflammation is sterile, as damage-associated molecular patterns rather than microbial pathogens elicit the response. The inflammasome, which leads...
Autores principales: | Freeman, Leslie, Guo, Haitao, David, Clément N., Brickey, W. June, Jha, Sushmita, Ting, Jenny P.-Y. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413320/ https://www.ncbi.nlm.nih.gov/pubmed/28404595 http://dx.doi.org/10.1084/jem.20150237 |
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