Different Somatic Hypermutation Levels among Antibody Subclasses Disclosed by a New Next-Generation Sequencing-Based Antibody Repertoire Analysis

A diverse antibody repertoire is primarily generated by the rearrangement of V, D, and J genes and subsequent somatic hypermutation (SHM). Class-switch recombination (CSR) produces various isotypes and subclasses with different functional properties. Although antibody isotypes and subclasses are con...

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Detalles Bibliográficos
Autores principales: Kitaura, Kazutaka, Yamashita, Hiroshi, Ayabe, Hitomi, Shini, Tadasu, Matsutani, Takaji, Suzuki, Ryuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413556/
https://www.ncbi.nlm.nih.gov/pubmed/28515723
http://dx.doi.org/10.3389/fimmu.2017.00389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413556/
https://www.ncbi.nlm.nih.gov/pubmed/28515723
http://dx.doi.org/10.3389/fimmu.2017.00389

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