Cargando…

Different Somatic Hypermutation Levels among Antibody Subclasses Disclosed by a New Next-Generation Sequencing-Based Antibody Repertoire Analysis

A diverse antibody repertoire is primarily generated by the rearrangement of V, D, and J genes and subsequent somatic hypermutation (SHM). Class-switch recombination (CSR) produces various isotypes and subclasses with different functional properties. Although antibody isotypes and subclasses are con...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kitaura, Kazutaka, Yamashita, Hiroshi, Ayabe, Hitomi, Shini, Tadasu, Matsutani, Takaji, Suzuki, Ryuji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413556/ https://www.ncbi.nlm.nih.gov/pubmed/28515723 http://dx.doi.org/10.3389/fimmu.2017.00389

Ejemplares similares

A new high-throughput sequencing method for determining diversity and similarity of T cell receptor (TCR) α and β repertoires and identifying potential new invariant TCR α chains
por: Kitaura, Kazutaka, et al.
Publicado: (2016)

Somatic Hypermutation Shapes the Antibody Repertoire of Memory B Cells in Humans
por: Meffre, Eric, et al.
Publicado: (2001)

Next-Generation Immune Repertoire Sequencing as a Clue to Elucidate the Landscape of Immune Modulation by Host–Gut Microbiome Interactions
por: Ichinohe, Tatsuo, et al.
Publicado: (2018)

Antibody Subclass Repertoire and Graft Outcome Following Solid Organ Transplantation
por: Valenzuela, Nicole M., et al.
Publicado: (2016)

Structural Basis of Antibody Conformation and Stability Modulation by Framework Somatic Hypermutation
por: Sheng, Zizhang, et al.
Publicado: (2022)

Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine Design
por: Schramm, Chaim A., et al.
Publicado: (2018)

Antibody Dynamics Simulation—A Mathematical Exploration of Clonal Deletion and Somatic Hypermutation
por: Xu, Zhaobin, et al.
Publicado: (2023)

Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice
Publicado: (1996)

Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity
por: Guo, Wenzhong, et al.
Publicado: (2010)

The V(H )gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus
por: Fraser, Nicola LW, et al.
Publicado: (2003)

Tandem Substitutions in Somatic Hypermutation
por: Sepúlveda-Yáñez, Julieta H., et al.
Publicado: (2022)

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
por: Sok, Devin, et al.
Publicado: (2013)

DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes
por: Maul, Robert W., et al.
Publicado: (2016)

Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans
por: IJspeert, Hanna, et al.
Publicado: (2019)

Next-Generation Sequencing of Antibody Display Repertoires
por: Rouet, Romain, et al.
Publicado: (2018)

Correction: The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
por: Sok, Devin, et al.
Publicado: (2013)

Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization
por: Jeong, Soo Lim, et al.
Publicado: (2022)

Attracting AID to targets of somatic hypermutation
por: Tanaka, Atsushi, et al.
Publicado: (2010)

Altered Immunoglobulin Repertoire and Decreased IgA Somatic Hypermutation in the Gut during Chronic HIV-1 Infection
por: Jones, Sean T., et al.
Publicado: (2022)

Accumulation of Metal-Specific T Cells in Inflamed Skin in a Novel Murine Model of Chromium-Induced Allergic Contact Dermatitis
por: Shigematsu, Hiroaki, et al.
Publicado: (2014)

AID function in somatic hypermutation and class switch recombination: AID function in somatic hypermutation and class switch recombination
por: Yu, Kefei
Publicado: (2022)

The Application of Next Generation Sequencing to the Understanding of Antibody Repertoires
por: Mathonet, Pascale, et al.
Publicado: (2013)

Highly functional T-cell receptor repertoires are abundant in stem memory T cells and highly shared among individuals
por: Miyama, Takahiko, et al.
Publicado: (2017)

Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity
por: Briney, Bryan S., et al.
Publicado: (2012)

Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation
por: Sheng, Zizhang, et al.
Publicado: (2017)

Evaluation of Somatic Hypermutation Status in Chronic Lymphocytic Leukemia (CLL) in the Era of Next Generation Sequencing
por: Gupta, Sanjeev Kumar, et al.
Publicado: (2020)

Characterization of T Cell Receptors of Th1 Cells Infiltrating Inflamed Skin of a Novel Murine Model of Palladium-Induced Metal Allergy
por: Kobayashi, Hiroshi, et al.
Publicado: (2013)

Identifying protein–protein interactions in somatic hypermutation
por: Goodman, Myron F., et al.
Publicado: (2005)

Recurrent targets of aberrant somatic hypermutation in lymphoma
por: Khodabakhshi, Alireza Hadj, et al.
Publicado: (2012)

Antibody lineages with evidence of somatic hypermutation persisting for >4 years in a South African subject with broad neutralizing activity
por: Moody, M, et al.
Publicado: (2012)

High Affinity Humanized Antibodies without Making Hybridomas; Immunization Paired with Mammalian Cell Display and In Vitro Somatic Hypermutation
por: McConnell, Audrey D., et al.
Publicado: (2012)

Somatic Hypermutation and Framework Mutations of Variable Region Contribute to Anti-Zika Virus-Specific Monoclonal Antibody Binding and Function
por: Tsuji, Isamu, et al.
Publicado: (2022)

The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy
por: Ahn, Sung-Min, et al.
Publicado: (2016)

Antibody repertoire sequencing analysis: Antibody repertoire sequencing analysis
por: Zhang, Senxin, et al.
Publicado: (2022)

Somatic hypermutation of an immunoglobulin mu heavy chain transgene
Publicado: (1993)

The Role of DNA Repair in Somatic Hypermutation of Immunoglobulin Genes
por: Kim, Nayun, et al.
Publicado: (1998)

UNG shapes the specificity of AID-induced somatic hypermutation
por: Pérez-Durán, Pablo, et al.
Publicado: (2012)

Checkpoint kinase 1 negatively regulates somatic hypermutation
por: Frankenberger, Samantha, et al.
Publicado: (2014)

Ultradeep analysis of tumor heterogeneity in regions of somatic hypermutation
por: Spence, Janice M, et al.
Publicado: (2015)

Restriction of AID activity and somatic hypermutation by PARP-1
por: Tepper, Sandra, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_bs3aog2vee6jjr39ft52ckumi2