An Improved Model of the Trypanosoma brucei CTP Synthetase Glutaminase Domain–Acivicin Complex

The natural product acivicin inhibits the glutaminase activity of cytidine triphosphate (CTP) synthetase and is a potent lead compound for drug discovery in the area of neglected tropical diseases, specifically trypanosomaisis. A 2.1‐Å‐resolution crystal structure of the acivicin adduct with the glu...

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Detalles Bibliográficos
Autores principales: Oliveira de Souza, Juliana, Dawson, Alice, Hunter, William N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413811/
https://www.ncbi.nlm.nih.gov/pubmed/28333400
http://dx.doi.org/10.1002/cmdc.201700118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413811/
https://www.ncbi.nlm.nih.gov/pubmed/28333400
http://dx.doi.org/10.1002/cmdc.201700118

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