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An Improved Model of the Trypanosoma brucei CTP Synthetase Glutaminase Domain–Acivicin Complex
The natural product acivicin inhibits the glutaminase activity of cytidine triphosphate (CTP) synthetase and is a potent lead compound for drug discovery in the area of neglected tropical diseases, specifically trypanosomaisis. A 2.1‐Å‐resolution crystal structure of the acivicin adduct with the glu...
Autores principales: | Oliveira de Souza, Juliana, Dawson, Alice, Hunter, William N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413811/ https://www.ncbi.nlm.nih.gov/pubmed/28333400 http://dx.doi.org/10.1002/cmdc.201700118 |
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