Development of an Efficient G‐Quadruplex‐Stabilised Thrombin‐Binding Aptamer Containing a Three‐Carbon Spacer Molecule

The thrombin‐binding aptamer (TBA), which shows anticoagulant properties, is one of the most studied G‐quadruplex‐forming aptamers. In this study, we investigated the impact of different chemical modifications such as a three‐carbon spacer (spacer‐C(3)), unlocked nucleic acid (UNA) and 3′‐amino‐modi...

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Detalles Bibliográficos
Autores principales: Aaldering, Lukas J., Poongavanam, Vasanthanathan, Langkjær, Niels, Murugan, N. Arul, Jørgensen, Per Trolle, Wengel, Jesper, Veedu, Rakesh N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413854/
https://www.ncbi.nlm.nih.gov/pubmed/28150905
http://dx.doi.org/10.1002/cbic.201600654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413854/
https://www.ncbi.nlm.nih.gov/pubmed/28150905
http://dx.doi.org/10.1002/cbic.201600654

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