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The Drosophila ZO-1 protein Polychaetoid suppresses Deltex-regulated Notch activity to modulate germline stem cell niche formation

The developmental signalling protein Notch can be proteolytically activated following ligand-interaction at the cell surface, or can be activated independently of its ligands, following Deltex (Dx)-induced Notch endocytosis and trafficking to the lysosomal membrane. The means by which different pool...

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Detalles Bibliográficos
Autores principales: Shimizu, Hideyuki, Wilkin, Marian B., Woodcock, Simon A., Bonfini, Alessandro, Hung, Yvonne, Mazaleyrat, Sabine, Baron, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413905/
https://www.ncbi.nlm.nih.gov/pubmed/28424321
http://dx.doi.org/10.1098/rsob.160322