Cargando…

Development of a core Clostridium thermocellum kinetic metabolic model consistent with multiple genetic perturbations

BACKGROUND: Clostridium thermocellum is a Gram-positive anaerobe with the ability to hydrolyze and metabolize cellulose into biofuels such as ethanol, making it an attractive candidate for consolidated bioprocessing (CBP). At present, metabolic engineering in C. thermocellum is hindered due to the i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dash, Satyakam, Khodayari, Ali, Zhou, Jilai, Holwerda, Evert K., Olson, Daniel G., Lynd, Lee R., Maranas, Costas D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414155/ https://www.ncbi.nlm.nih.gov/pubmed/28469704 http://dx.doi.org/10.1186/s13068-017-0792-2

Ejemplares similares

Metabolic Fluxes of Nitrogen and Pyrophosphate in Chemostat Cultures of Clostridium thermocellum and Thermoanaerobacterium saccharolyticum
por: Holwerda, Evert K., et al.
Publicado: (2020)

Simultaneous achievement of high ethanol yield and titer in Clostridium thermocellum
por: Tian, Liang, et al.
Publicado: (2016)

Laboratory Evolution and Reverse Engineering of Clostridium thermocellum for Growth on Glucose and Fructose
por: Yayo, Johannes, et al.
Publicado: (2021)

Rheological properties of corn stover slurries during fermentation by Clostridium thermocellum
por: Ghosh, Sanchari, et al.
Publicado: (2018)

The exometabolome of Clostridium thermocellum reveals overflow metabolism at high cellulose loading
por: Holwerda, Evert K, et al.
Publicado: (2014)

Declining carbohydrate solubilization with increasing solids loading during fermentation of cellulosic feedstocks by Clostridium thermocellum: documentation and diagnostic tests
por: Kubis, Matthew R., et al.
Publicado: (2022)

Development of a Genome-Scale Metabolic Model of Clostridium thermocellum and Its Applications for Integration of Multi-Omics Datasets and Computational Strain Design
por: Garcia, Sergio, et al.
Publicado: (2020)

Metabolic and evolutionary responses of Clostridium thermocellum to genetic interventions aimed at improving ethanol production
por: Holwerda, Evert K., et al.
Publicado: (2020)

Expressing the Thermoanaerobacterium saccharolyticum pforA in engineered Clostridium thermocellum improves ethanol production
por: Hon, Shuen, et al.
Publicado: (2018)

Enhanced ethanol formation by Clostridium thermocellum via pyruvate decarboxylase
por: Tian, Liang, et al.
Publicado: (2017)

In Vivo Thermodynamic Analysis of Glycolysis in Clostridium thermocellum and Thermoanaerobacterium saccharolyticum Using (13)C and (2)H Tracers
por: Jacobson, Tyler B., et al.
Publicado: (2020)

Identifying promoters for gene expression in Clostridium thermocellum
por: Olson, Daniel G., et al.
Publicado: (2015)

Dcm methylation is detrimental to plasmid transformation in Clostridium thermocellum
por: Guss, Adam M, et al.
Publicado: (2012)

Elimination of formate production in Clostridium thermocellum
por: Rydzak, Thomas, et al.
Publicado: (2015)

Expression of adhA from different organisms in Clostridium thermocellum
por: Zheng, Tianyong, et al.
Publicado: (2017)

Functional Analysis of H(+)-Pumping Membrane-Bound Pyrophosphatase, ADP-Glucose Synthase, and Pyruvate Phosphate Dikinase as Pyrophosphate Sources in Clostridium thermocellum
por: Kuil, Teun, et al.
Publicado: (2022)

Biomass augmentation through thermochemical pretreatments greatly enhances digestion of switchgrass by Clostridium thermocellum
por: Kothari, Ninad, et al.
Publicado: (2018)

Ethanol tolerance in engineered strains of Clostridium thermocellum
por: Olson, Daniel G., et al.
Publicado: (2023)

Tracking the cellulolytic activity of Clostridium thermocellum biofilms
por: Dumitrache, Alexandru, et al.
Publicado: (2013)

Metabolic engineering of Clostridium thermocellum for n-butanol production from cellulose
por: Tian, Liang, et al.
Publicado: (2019)

Clostridium thermocellum DSM 1313 transcriptional responses to redox perturbation
por: Sander, Kyle, et al.
Publicado: (2015)

Formation and characterization of non-growth states in Clostridium thermocellum: spores and L-forms
por: Mearls, Elizabeth B, et al.
Publicado: (2012)

A genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains
por: Khodayari, Ali, et al.
Publicado: (2016)

Elimination of hydrogenase active site assembly blocks H(2) production and increases ethanol yield in Clostridium thermocellum
por: Biswas, Ranjita, et al.
Publicado: (2015)

Comparative analysis of the ability of Clostridium clariflavum strains and Clostridium thermocellum to utilize hemicellulose and unpretreated plant material
por: Izquierdo, Javier A, et al.
Publicado: (2014)

Capturing the response of Clostridium acetobutylicum to chemical stressors using a regulated genome-scale metabolic model
por: Dash, Satyakam, et al.
Publicado: (2014)

Functional heterologous expression of an engineered full length CipA from Clostridium thermocellum in Thermoanaerobacterium saccharolyticum
por: Currie, Devin H, et al.
Publicado: (2013)

Promiscuous plasmid replication in thermophiles: Use of a novel hyperthermophilic replicon for genetic manipulation of Clostridium thermocellum at its optimum growth temperature
por: Groom, Joseph, et al.
Publicado: (2016)

Improved growth rate in Clostridium thermocellum hydrogenase mutant via perturbed sulfur metabolism
por: Biswas, Ranjita, et al.
Publicado: (2017)

Increase in Ethanol Yield via Elimination of Lactate Production in an Ethanol-Tolerant Mutant of Clostridium thermocellum
por: Biswas, Ranjita, et al.
Publicado: (2014)

Dramatic performance of Clostridium thermocellum explained by its wide range of cellulase modalities
por: Xu, Qi, et al.
Publicado: (2016)

A mutation in the AdhE alcohol dehydrogenase of Clostridium thermocellum increases tolerance to several primary alcohols, including isobutanol, n-butanol and ethanol
por: Tian, Liang, et al.
Publicado: (2019)

Metabolic Adaption of Ethanol-Tolerant Clostridium thermocellum
por: Zhu, Xinshu, et al.
Publicado: (2013)

Deciphering Cellodextrin and Glucose Uptake in Clostridium thermocellum
por: Yan, Fei, et al.
Publicado: (2022)

Development of both type I–B and type II CRISPR/Cas genome editing systems in the cellulolytic bacterium Clostridium thermocellum
por: Walker, Julie E., et al.
Publicado: (2019)

Succinate Overproduction: A Case Study of Computational Strain Design Using a Comprehensive Escherichia coli Kinetic Model
por: Khodayari, Ali, et al.
Publicado: (2015)

Modeling Growth Kinetics, Interspecies Cell Fusion, and Metabolism of a Clostridium acetobutylicum/Clostridium ljungdahlii Syntrophic Coculture
por: Foster, Charles, et al.
Publicado: (2021)

Development of a plasmid-based expression system in Clostridium thermocellum and its use to screen heterologous expression of bifunctional alcohol dehydrogenases (adhEs)
por: Hon, Shuen, et al.
Publicado: (2016)

Application of Long Sequence Reads To Improve Genomes for Clostridium thermocellum AD2, Clostridium thermocellum LQRI, and Pelosinus fermentans R7
por: Utturkar, Sagar M., et al.
Publicado: (2016)

Coculture with hemicellulose-fermenting microbes reverses inhibition of corn fiber solubilization by Clostridium thermocellum at elevated solids loadings
por: Beri, Dhananjay, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nfjfq5viv1r4nira3pdd5nai60