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Inferring the physical properties of yeast chromatin through Bayesian analysis of whole nucleus simulations

BACKGROUND: The structure and mechanical properties of chromatin impact DNA functions and nuclear architecture but remain poorly understood. In budding yeast, a simple polymer model with minimal sequence-specific constraints and a small number of structural parameters can explain diverse experimenta...

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Detalles Bibliográficos
Autores principales: Arbona, Jean-Michel, Herbert, Sébastien, Fabre, Emmanuelle, Zimmer, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414205/
https://www.ncbi.nlm.nih.gov/pubmed/28468672
http://dx.doi.org/10.1186/s13059-017-1199-x