Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways

BACKGROUND: Mesothelioma is resistant to conventional treatments and is often defective in p53 pathways. We then examined anti-tumor effects of metformin, an agent for type 2 diabetes, and combinatory effects of metformin and nutlin-3a, an inhibitor for ubiquitin-mediated p53 degradation, on human m...

Descripción completa

Detalles Bibliográficos
Autores principales: Shimazu, Kengo, Tada, Yuji, Morinaga, Takao, Shingyoji, Masato, Sekine, Ikuo, Shimada, Hideaki, Hiroshima, Kenzo, Namiki, Takao, Tatsumi, Koichiro, Tagawa, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414226/
https://www.ncbi.nlm.nih.gov/pubmed/28464864
http://dx.doi.org/10.1186/s12885-017-3300-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414226/
https://www.ncbi.nlm.nih.gov/pubmed/28464864
http://dx.doi.org/10.1186/s12885-017-3300-y

Ejemplares similares