Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

Nucleic acid editing enzymes are essential components of the immune system that lethally mutate viral pathogens and somatically mutate immunoglobulins, and contribute to the diversification and lethality of cancers. Among these enzymes are the seven human APOBEC3 deoxycytidine deaminases, each with...

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Detalles Bibliográficos
Autores principales: Kouno, Takahide, Silvas, Tania V., Hilbert, Brendan J., Shandilya, Shivender M. D., Bohn, Markus F., Kelch, Brian A., Royer, William E., Somasundaran, Mohan, Kurt Yilmaz, Nese, Matsuo, Hiroshi, Schiffer, Celia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414352/
https://www.ncbi.nlm.nih.gov/pubmed/28452355
http://dx.doi.org/10.1038/ncomms15024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414352/
https://www.ncbi.nlm.nih.gov/pubmed/28452355
http://dx.doi.org/10.1038/ncomms15024

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