HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

High-mobility group A1 (Hmga1) chromatin remodelling proteins are enriched in intestinal stem cells (ISCs), although their function in this setting was unknown. Prior studies showed that Hmga1 drives hyperproliferation, aberrant crypt formation and polyposis in transgenic mice. Here we demonstrate t...

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Detalles Bibliográficos
Autores principales: Xian, Lingling, Georgess, Dan, Huso, Tait, Cope, Leslie, Belton, Amy, Chang, Yu-Ting, Kuang, Wenyong, Gu, Qihua, Zhang, Xiaoyan, Senger, Stefania, Fasano, Alessio, Huso, David L., Ewald, Andrew J., Resar, Linda M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414379/
https://www.ncbi.nlm.nih.gov/pubmed/28452345
http://dx.doi.org/10.1038/ncomms15008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414379/
https://www.ncbi.nlm.nih.gov/pubmed/28452345
http://dx.doi.org/10.1038/ncomms15008

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