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Recent advances in understanding Cushing disease: resistance to glucocorticoid negative feedback and somatic USP8 mutations
Cushing’s disease is a rare disease with a characteristic phenotype due to significant hypercortisolism driven by over-secretion of adrenocorticotropic hormone and to high morbidity and mortality if untreated. It is caused by a corticotroph adenoma of the pituitary, but the exact mechanisms leading...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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F1000Research
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414817/ https://www.ncbi.nlm.nih.gov/pubmed/28529722 http://dx.doi.org/10.12688/f1000research.10968.1 |