Aberrant caveolin-1–mediated Smad signaling and proliferation identified by analysis of adenine 474 deletion mutation (c.474delA) in patient fibroblasts: a new perspective on the mechanism of pulmonary hypertension

A heterozygous caveolin-1 c.474delA mutation has been identified in a family with heritable pulmonary arterial hypertension (PAH). This frameshift mutation leads to a caveolin-1 protein that contains all known functional domains but has a change in only the final 20 amino acids of the C-terminus. He...

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Detalles Bibliográficos
Autores principales: Marsboom, Glenn, Chen, Zhenlong, Yuan, Yang, Zhang, Yanmin, Tiruppathi, Chinnaswamy, Loyd, James E., Austin, Eric D., Machado, Roberto F., Minshall, Richard D., Rehman, Jalees, Malik, Asrar B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415014/
https://www.ncbi.nlm.nih.gov/pubmed/28468941
http://dx.doi.org/10.1091/mbc.E16-11-0790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415014/
https://www.ncbi.nlm.nih.gov/pubmed/28468941
http://dx.doi.org/10.1091/mbc.E16-11-0790

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