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Aberrant caveolin-1–mediated Smad signaling and proliferation identified by analysis of adenine 474 deletion mutation (c.474delA) in patient fibroblasts: a new perspective on the mechanism of pulmonary hypertension
A heterozygous caveolin-1 c.474delA mutation has been identified in a family with heritable pulmonary arterial hypertension (PAH). This frameshift mutation leads to a caveolin-1 protein that contains all known functional domains but has a change in only the final 20 amino acids of the C-terminus. He...
Autores principales: | Marsboom, Glenn, Chen, Zhenlong, Yuan, Yang, Zhang, Yanmin, Tiruppathi, Chinnaswamy, Loyd, James E., Austin, Eric D., Machado, Roberto F., Minshall, Richard D., Rehman, Jalees, Malik, Asrar B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415014/ https://www.ncbi.nlm.nih.gov/pubmed/28468941 http://dx.doi.org/10.1091/mbc.E16-11-0790 |
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