Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency

Kaposi Sarcoma Herpesvirus (KSHV), a γ2-herpesvirus and class 1 carcinogen, is responsible for at least three human malignancies: Kaposi Sarcoma (KS), Primary Effusion Lymphoma (PEL) and Multicentric Castleman’s Disease (MCD). Its major nuclear latency protein, LANA, is indispensable for the mainten...

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Detalles Bibliográficos
Autores principales: Mariggiò, Giuseppe, Koch, Sandra, Zhang, Guigen, Weidner-Glunde, Magdalena, Rückert, Jessica, Kati, Semra, Santag, Susann, Schulz, Thomas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415203/
https://www.ncbi.nlm.nih.gov/pubmed/28430817
http://dx.doi.org/10.1371/journal.ppat.1006335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415203/
https://www.ncbi.nlm.nih.gov/pubmed/28430817
http://dx.doi.org/10.1371/journal.ppat.1006335

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