The 2.8 Å Electron Microscopy Structure of Adeno-Associated Virus-DJ Bound by a Heparinoid Pentasaccharide

Atomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 Å resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously derived by directed evolution, selecting for hepatocy...

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Detalles Bibliográficos
Autores principales: Xie, Qing, Spear, John M., Noble, Alex J., Sousa, Duncan R., Meyer, Nancy L., Davulcu, Omar, Zhang, Fuming, Linhardt, Robert J., Stagg, Scott M., Chapman, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415311/
https://www.ncbi.nlm.nih.gov/pubmed/28480299
http://dx.doi.org/10.1016/j.omtm.2017.02.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415311/
https://www.ncbi.nlm.nih.gov/pubmed/28480299
http://dx.doi.org/10.1016/j.omtm.2017.02.004

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