PRC2 represses transcribed genes on the imprinted inactive X chromosome in mice

BACKGROUND: Polycomb repressive complex 2 (PRC2) catalyzes histone H3K27me3, which marks many transcriptionally silent genes throughout the mammalian genome. Although H3K27me3 is associated with silenced gene expression broadly, it remains unclear why some but not other PRC2 target genes require PRC...

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Detalles Bibliográficos
Autores principales: Maclary, Emily, Hinten, Michael, Harris, Clair, Sethuraman, Shriya, Gayen, Srimonta, Kalantry, Sundeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415793/
https://www.ncbi.nlm.nih.gov/pubmed/28468635
http://dx.doi.org/10.1186/s13059-017-1211-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415793/
https://www.ncbi.nlm.nih.gov/pubmed/28468635
http://dx.doi.org/10.1186/s13059-017-1211-5

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