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Subcellular Chemical Imaging of Antibiotics in Single Bacteria Using C(60)-Secondary Ion Mass Spectrometry

[Image: see text] The inherent difficulty of discovering new and effective antibacterials and the rapid development of resistance particularly in Gram-negative bacteria, illustrates the urgent need for new methods that enable rational drug design. Here we report the development of 3D imaging cluster...

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Detalles Bibliográficos
Autores principales: Tian, Hua, Six, David A., Krucker, Thomas, Leeds, Jennifer A., Winograd, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415874/
https://www.ncbi.nlm.nih.gov/pubmed/28332827
http://dx.doi.org/10.1021/acs.analchem.7b00466