Metformin alters DNA methylation genome-wide via the H19/SAHH axis

The molecular mechanisms underlying the antineoplastic properties of metformin, a first-line drug for type 2 diabetes, remain elusive. Here we report that metformin induces genome-wide alterations in DNA methylation by modulating the activity of S-adenosylhomocysteine hydrolase (SAHH). Exposing canc...

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Detalles Bibliográficos
Autores principales: Zhong, T, Men, Y, Lu, L, Geng, T, Zhou, J, Mitsuhashi, A, Shozu, M, Maihle, N J, Carmichael, G G, Taylor, H S, Huang, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415944/
https://www.ncbi.nlm.nih.gov/pubmed/27775072
http://dx.doi.org/10.1038/onc.2016.391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415944/
https://www.ncbi.nlm.nih.gov/pubmed/27775072
http://dx.doi.org/10.1038/onc.2016.391

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