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Metformin alters DNA methylation genome-wide via the H19/SAHH axis
The molecular mechanisms underlying the antineoplastic properties of metformin, a first-line drug for type 2 diabetes, remain elusive. Here we report that metformin induces genome-wide alterations in DNA methylation by modulating the activity of S-adenosylhomocysteine hydrolase (SAHH). Exposing canc...
Autores principales: | Zhong, T, Men, Y, Lu, L, Geng, T, Zhou, J, Mitsuhashi, A, Shozu, M, Maihle, N J, Carmichael, G G, Taylor, H S, Huang, Y |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415944/ https://www.ncbi.nlm.nih.gov/pubmed/27775072 http://dx.doi.org/10.1038/onc.2016.391 |
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