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FTY720 elevates smooth muscle contraction of aorta and blood pressure in rats via ERK activation

Sphingosine 1‐phosphate (S1P) is an important signaling sphingolipid involved in the pathogenesis of various cardio cerebral vascular diseases such as ischemic stroke. In particular, the S1P mimetic FTY720 is protective for brain against ischemic conditions. However, whether and how FTY720 can modul...

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Detalles Bibliográficos
Autores principales: Zhao, Zhen, Wang, Jinxin, Huo, Zhijun, Wang, Zhiyong, Mei, Qibing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415948/
https://www.ncbi.nlm.nih.gov/pubmed/28480040
http://dx.doi.org/10.1002/prp2.308