Expression of Herpes Simplex Virus Thymidine Kinase/Ganciclovir by RNA Trans-Splicing Induces Selective Killing of HIV-Producing Cells

Antiviral strategies targeting hijacked cellular processes are less easily evaded by the virus than viral targets. If selective for viral functions, they can have a high therapeutic index. We used RNA trans-splicing to deliver the herpes simplex virus thymidine kinase-ganciclovir (HSV-tk/GCV) cell s...

Descripción completa

Detalles Bibliográficos
Autores principales: Ingemarsdotter, Carin K., Poddar, Sushmita, Mercier, Sarah, Patzel, Volker, Lever, Andrew M.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415956/
https://www.ncbi.nlm.nih.gov/pubmed/28624190
http://dx.doi.org/10.1016/j.omtn.2017.03.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415956/
https://www.ncbi.nlm.nih.gov/pubmed/28624190
http://dx.doi.org/10.1016/j.omtn.2017.03.004

Ejemplares similares