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Expression of Herpes Simplex Virus Thymidine Kinase/Ganciclovir by RNA Trans-Splicing Induces Selective Killing of HIV-Producing Cells

Antiviral strategies targeting hijacked cellular processes are less easily evaded by the virus than viral targets. If selective for viral functions, they can have a high therapeutic index. We used RNA trans-splicing to deliver the herpes simplex virus thymidine kinase-ganciclovir (HSV-tk/GCV) cell s...

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Detalles Bibliográficos
Autores principales:	Ingemarsdotter, Carin K., Poddar, Sushmita, Mercier, Sarah, Patzel, Volker, Lever, Andrew M.L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415956/ https://www.ncbi.nlm.nih.gov/pubmed/28624190 http://dx.doi.org/10.1016/j.omtn.2017.03.004

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