Cargando…
Assessing the presence of shared genetic architecture between Alzheimer's disease and major depressive disorder using genome-wide association data
Major depressive disorder (MDD) and Alzheimer's disease (AD) are both common in older age and frequently co-occur. Numerous phenotypic studies based on clinical diagnoses suggest that a history of depression increases risk of subsequent AD, although the basis of this relationship is uncertain....
Autores principales: | Gibson, J, Russ, T C, Adams, M J, Clarke, T-K, Howard, D M, Hall, L S, Fernandez-Pujals, A M, Wigmore, E M, Hayward, C, Davies, G, Murray, A D, Smith, B H, Porteous, D J, Deary, I J, McIntosh, A M |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416691/ https://www.ncbi.nlm.nih.gov/pubmed/28418403 http://dx.doi.org/10.1038/tp.2017.49 |
Ejemplares similares
-
Do regional brain volumes and major depressive disorder share genetic architecture? A study of Generation Scotland (n=19 762), UK Biobank (n=24 048) and the English Longitudinal Study of Ageing (n=5766)
por: Wigmore, E M, et al.
Publicado: (2017) -
Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts
por: Whalley, H C, et al.
Publicado: (2016) -
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117)
por: Clarke, T-K, et al.
Publicado: (2017) -
Major depressive disorder and current psychological distress moderate the effect of polygenic risk for obesity on body mass index
por: Clarke, T-K, et al.
Publicado: (2015) -
Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population
por: Clarke, Toni-Kim, et al.
Publicado: (2019)