Body-hypomethylated human genes harbor extensive intragenic transcriptional activity and are prone to cancer-associated dysregulation

Genomic DNA methylation maps (methylomes) encode genetic and environmental effects as stable chemical modifications of DNA. Variations in DNA methylation, especially in regulatory regions such as promoters and enhancers, are known to affect numerous downstream processes. In contrast, most transcript...

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Detalles Bibliográficos
Autores principales: Mendizabal, Isabel, Zeng, Jia, Keller, Thomas E., Yi, Soojin V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416765/
https://www.ncbi.nlm.nih.gov/pubmed/28115635
http://dx.doi.org/10.1093/nar/gkx020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416765/
https://www.ncbi.nlm.nih.gov/pubmed/28115635
http://dx.doi.org/10.1093/nar/gkx020

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