Human CTF18-RFC clamp-loader complexed with non-synthesising DNA polymerase ε efficiently loads the PCNA sliding clamp

The alternative proliferating-cell nuclear antigen (PCNA)-loader CTF18-RFC forms a stable complex with DNA polymerase ε (Polε). We observed that, under near-physiological conditions, CTF18-RFC alone loaded PCNA inefficiently, but loaded it efficiently when complexed with Polε. During efficient PCNA...

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Detalles Bibliográficos
Autores principales: Fujisawa, Ryo, Ohashi, Eiji, Hirota, Kouji, Tsurimoto, Toshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416766/
https://www.ncbi.nlm.nih.gov/pubmed/28199690
http://dx.doi.org/10.1093/nar/gkx096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416766/
https://www.ncbi.nlm.nih.gov/pubmed/28199690
http://dx.doi.org/10.1093/nar/gkx096

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