SF3b1 mutations associated with myelodysplastic syndromes alter the fidelity of branchsite selection in yeast

RNA and protein components of the spliceosome work together to identify the 5΄ splice site, the 3΄ splice site, and the branchsite (BS) of nascent pre-mRNA. SF3b1 plays a key role in recruiting the U2 snRNP to the BS. Mutations in human SF3b1 have been linked to many diseases such as myelodysplasia...

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Detalles Bibliográficos
Autores principales: Carrocci, Tucker J., Zoerner, Douglas M., Paulson, Joshua C., Hoskins, Aaron A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416834/
https://www.ncbi.nlm.nih.gov/pubmed/28062854
http://dx.doi.org/10.1093/nar/gkw1349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416834/
https://www.ncbi.nlm.nih.gov/pubmed/28062854
http://dx.doi.org/10.1093/nar/gkw1349

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