Cargando…
SF3b1 mutations associated with myelodysplastic syndromes alter the fidelity of branchsite selection in yeast
RNA and protein components of the spliceosome work together to identify the 5΄ splice site, the 3΄ splice site, and the branchsite (BS) of nascent pre-mRNA. SF3b1 plays a key role in recruiting the U2 snRNP to the BS. Mutations in human SF3b1 have been linked to many diseases such as myelodysplasia...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416834/ https://www.ncbi.nlm.nih.gov/pubmed/28062854 http://dx.doi.org/10.1093/nar/gkw1349 |