Clustered abasic lesions profoundly change the structure and stability of human telomeric G-quadruplexes

Ionizing radiation produces clustered damage to DNA which is difficult to repair and thus more harmful than single lesions. Clustered lesions have only been investigated in dsDNA models. Introducing the term ‘clustered damage to G-quadruplexes’ we report here on the structural effects of multiple te...

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Detalles Bibliográficos
Autores principales: Kejnovská, Iva, Bednářová, Klára, Renčiuk, Daniel, Dvořáková, Zuzana, Školáková, Petra, Trantírek, Lukáš, Fiala, Radovan, Vorlíčková, Michaela, Sagi, Janos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416849/
https://www.ncbi.nlm.nih.gov/pubmed/28369584
http://dx.doi.org/10.1093/nar/gkx191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416849/
https://www.ncbi.nlm.nih.gov/pubmed/28369584
http://dx.doi.org/10.1093/nar/gkx191

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