Aicardi–Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion

Maintaining genome integrity is important for cells and damaged DNA triggers autoimmunity. Previous studies have reported that Three-prime repair exonuclease 1(TREX1), an endogenous DNA exonuclease, prevents immune activation by depleting damaged DNA, thus preventing the development of certain autoi...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Peng, Du, Juan, Goodier, John L., Hou, Jingwei, Kang, Jian, Kazazian, Haig H., Zhao, Ke, Yu, Xiao-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416883/
https://www.ncbi.nlm.nih.gov/pubmed/28334850
http://dx.doi.org/10.1093/nar/gkx178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416883/
https://www.ncbi.nlm.nih.gov/pubmed/28334850
http://dx.doi.org/10.1093/nar/gkx178

Ejemplares similares