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Aicardi–Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion

Maintaining genome integrity is important for cells and damaged DNA triggers autoimmunity. Previous studies have reported that Three-prime repair exonuclease 1(TREX1), an endogenous DNA exonuclease, prevents immune activation by depleting damaged DNA, thus preventing the development of certain autoi...

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Detalles Bibliográficos
Autores principales:	Li, Peng, Du, Juan, Goodier, John L., Hou, Jingwei, Kang, Jian, Kazazian, Haig H., Zhao, Ke, Yu, Xiao-Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416883/ https://www.ncbi.nlm.nih.gov/pubmed/28334850 http://dx.doi.org/10.1093/nar/gkx178

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