CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance

To prevent progressive telomere shortening as a result of conventional DNA replication, new telomeric DNA must be added onto the chromosome end. The de novo DNA synthesis involves elongation of the G-rich strand of the telomere by telomerase. In human cells, the CST complex (CTC1-STN1-TEN1) also fun...

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Detalles Bibliográficos
Autores principales: Feng, Xuyang, Hsu, Shih-Jui, Kasbek, Christopher, Chaiken, Mary, Price, Carolyn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416890/
https://www.ncbi.nlm.nih.gov/pubmed/28334750
http://dx.doi.org/10.1093/nar/gkx125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416890/
https://www.ncbi.nlm.nih.gov/pubmed/28334750
http://dx.doi.org/10.1093/nar/gkx125

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