Acid- and Au(i)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures

Libraries of DNA-tagged compounds are a validated screening technology for drug discovery. They are synthesized through combinatorial iterations of alternated coding and preparative synthesis steps. Thus, large chemical space can be accessed for target-based screening. However, the need to preserve...

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Detalles Bibliográficos
Autores principales: Škopić, Mateja Klika, Salamon, Hazem, Bugain, Olivia, Jung, Kathrin, Gohla, Anne, Doetsch, Lara J., dos Santos, Denise, Bhat, Avinash, Wagner, Bernd, Brunschweiger, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416911/
https://www.ncbi.nlm.nih.gov/pubmed/28507705
http://dx.doi.org/10.1039/c7sc00455a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416911/
https://www.ncbi.nlm.nih.gov/pubmed/28507705
http://dx.doi.org/10.1039/c7sc00455a

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