Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies

The binding of Src-homology 2 (SH2) domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the eight Src family kinases (SFKs). The high sequence conservation of the 120 human SH2 domains poses a significant challenge to selectively perturb the interact...

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Detalles Bibliográficos
Autores principales: Kükenshöner, Tim, Schmit, Nadine Eliane, Bouda, Emilie, Sha, Fern, Pojer, Florence, Koide, Akiko, Seeliger, Markus, Koide, Shohei, Hantschel, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417323/
https://www.ncbi.nlm.nih.gov/pubmed/28347651
http://dx.doi.org/10.1016/j.jmb.2017.03.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417323/
https://www.ncbi.nlm.nih.gov/pubmed/28347651
http://dx.doi.org/10.1016/j.jmb.2017.03.023

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