In vitro visualization and characterization of wild type and mutant IDH homo- and heterodimers using Bimolecular Fluorescence Complementation

Mutations in the metabolic enzyme isocitrate dehydrogenase (IDH) were recently found in ~80% of WHO grade II–III gliomas and secondary glioblastomas. These mutations reduce the enzyme’s ability to convert isocitrate to α-ketoglutarate and, instead, confer a novel gain-of-function resulting in the co...

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Detalles Bibliográficos
Autores principales: Robinson, Gemma L., Philip, Beatrice, Guthrie, Matthew R., Cox, James E., Robinson, James P., VanBrocklin, Matthew W., Holmen, Sheri L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417691/
https://www.ncbi.nlm.nih.gov/pubmed/28480226
http://dx.doi.org/10.17980/2016.311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417691/
https://www.ncbi.nlm.nih.gov/pubmed/28480226
http://dx.doi.org/10.17980/2016.311

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