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A prion-like mechanism for the propagated misfolding of SOD1 from in silico modeling of solvated near-native conformers
A prion-like mechanism has been developed to explain the observed promotion of amyloid aggregation caused by conversion of structurally intact SOD1 to a misfolded form. Superoxide dismutase [Cu-Zn], or SOD1, is a homo-dimeric protein that functions as an antioxidant by scavenging for superoxide. The...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417709/ https://www.ncbi.nlm.nih.gov/pubmed/28472188 http://dx.doi.org/10.1371/journal.pone.0177284 |